Rules FAQ
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Highgarden Sept stops all card abilities that would put non-The Seven characters into play, as well as characters returning to play after being removed from the game (for instance, due to Mace Tyrell (R) or Coldhands). If a character that was removed from the game cannot return when its removal effect expires, that character stays removed from the game indefinitely.
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If you use Mace Tyrell (R) during the challenges phase, the character will return to play at the beginning of the dominance phase, so Highgarden Sept will not prevent it from returning to play.